About Iron Sucrose (Available For Selected Markets) API
Therapeutic CategoryNephrology
CAS Number
8047-67-4
API Technology
Iron Product
Dose Form
Injectable
Dr Reddy's Development Status
Available
Available Regulatory Filing
USDMF, Brazil DMF
Mechanism of Action
Venofer is an aqueous complex of poly-nuclear iron (III)-hydroxide in sucrose. Following intravenous administration, Venofer is dissociated into iron and sucrose and the iron is transported as a complex with transferrin to target cells including erythroid precursor cells. The iron in the precursor cells is incorporated into hemoglobin as the cells mature into red blood cells.
Indication
Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD).
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Related Resources
Colloidal Iron Complex Formulations – Understanding and Developing the Process
This whitepaper describes the challenges involved in developing iron-carbohydrate complexes, including the parameters required to demonstrate physicochemical equivalence and summarises our expertise in addressing them.
Iron carbohydrate complexes are a hybrid of inorganic and organic molecules. The molecule's key structural elements are architected /governed by the defined process unit operations and materials used in the process. Any subtle variation in the process unit operation can alter the structural features of the iron carbohydrate complex
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