About Ketorolac Tromethamine API
Therapeutic CategoryTratamiento del dolor
CAS Number
74103-07-4
API Technology
Synthetic
Dose Form
Nasal
Dr Reddy's Development Status
Available
Available Regulatory Filing
China DMF, USDMF, CEP Submitted, Brazil DMF, Korea DMF, Russia DMF
Mechanism of Action
Ketorolac has analgesic, anti-inflammatory, and antipyretic properties.
The mechanism of action of SPRIX, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2), an early component of the arachidonic acid cascade, resulting in the reduced synthesis of prostaglandins, thromboxanes, and prostacyclin.
Ketorolac is a potent inhibitor of prostaglandin synthesis in vitro. Ketorolac concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because ketorolac is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.
Indication
SPRIX is a nonsteroidal anti-inflammatory drug indicated in adult patients for the short term (up to 5 days) management of moderate to moderately severe pain that requires analgesia at the opioid level.
Related APIs
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Ketorolaco Trometamina
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Naproxeno
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Naratriptán Clorhidrato
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Succinato De Sumatriptán
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FAQs
Blood pressure (BP) should be monitored closely during the initiation of NSAID treatment and throughout the course of therapy.
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50 kg or more: 31.5 mg every 6 to 8 hours; less than 50 kg: 15.75 mg (1 spray in each nostril). 15 or 30 mg, injected into a muscle or a vein four times a day.
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To relieve moderately severe pain, usually after surgery.
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It belongs to the group of medicines called nonsteroidal anti-inflammatory drugs (NSAIDs).
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We offer Crystalline form
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