Mechanism of Action

Naproxen has analgesic, anti-inflammatory, and antipyretic properties.

The mechanism of action of NAPRELAN, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).

Naproxen sodium is a potent inhibitor of prostaglandin synthesis in vitro. Naproxen sodium concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because naproxen sodium is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.

Indication

NAPRELAN is a nonsteroidal anti-inflammatory drug indicated for the treatment of:

• Rheumatoid arthritis (RA)
• Osteoarthritis (OA)
• Ankylosing spondylitis (AS)
• Tendinitis, bursitis
• Acute gout
• Primary dysmenorrhea (PD)
• The relief of mild to moderate pain