About Naproxen API
Therapeutic CategoryPain Management
API Technology
Synthetic
Dose Form
Suspension, Tablets
Dr Reddy's Development Status
Available
Available Regulatory Filing
USDMF, CEP Submitted, Brazil DMF, Canada DMF, Japan DMF, Korea DMF, Russia DMF, China DMF
Mechanism of Action
Naproxen has analgesic, anti-inflammatory, and antipyretic properties. ANAPROX DS (naproxen sodium) has been developed as a more rapidly absorbed formulation of naproxen for use as an analgesic.
The mechanism of action of naproxen, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).
Naproxen is a potent inhibitor of prostaglandin synthesis in vitro. Naproxen concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because naproxen is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.
Indication
NAPROSYN Tablets, EC-NAPROSYN, and ANAPROX DS are non-steroidal anti-inflammatory drugs indicated for the relief of the signs and symptoms of:
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Polyarticular juvenile idiopathic arthritis
NAPROSYN Tablets and ANAPROX DS are also indicated for the relief of signs and symptoms of:
- Tendonitis
- Bursitis
- Acute gout the manage ment of
- Pain
- Primary dysmenorrhea
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FAQs
Pain relief from indications such as headache, muscle ache, tendonitis, dental pain, and menstrual cramps. Also reduces swelling, pain, and joint stiffness caused by arthritis, bursitis, and gout attacks.
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Adults—550 milligrams (mg) for the first dose, then 550 mg every 12 hours or 275 mg every 6 to 8 hours as needed.
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We offer Polymorphic Form-I
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