About Terbinafine Hydrochloride API
Therapeutic CategoryAnti-Infective
CAS Number
78628-80-5
API Technology
Synthetic
Dose Form
Topical Gel, Cream, Solution, Spray
Dr Reddy's Development Status
Available
Available Regulatory Filing
USDMF, CEP Submitted, Japan DMF, Korea DMF
Mechanism of Action
Terbinafine inhibits the enzyme squalene monooxygenase (also called squalene epoxidase), preventing the conversion of squalene to 2,3-oxydosqualene, a step in the synthesis of ergosterol. This inhibition leads to decreased ergosterol, which would normally be incorporated into the cell wall, and accumulation of squalene. Generation of a large number of squalene containing vesicles in the cytoplasm may leach other lipids away from, and further weaken, the cell wall.
Indication
Terbinafine Hydrochloride is used to treat various fungal skin infections such as ringworm, athlete's foot, and jock itch. This medication is also used to treat a skin condition known as pityriasis (tinea versicolor), a fungal infection that causes a lightening or darkening of the skin of the neck, chest, arms, or legs. Terbinafine is an antifungal that works by preventing the growth of fungus.
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