CAS Number: 1138245-21-2
Miragabalin is a novel, orally-administered small molecule that acts as a selective modulator of alpha2-delta subunit of voltage-gated calcium channels in the central nervous system.
The alpha2-delta subunit is expressed in dorsal root ganglia and is involved in regulation of neurotransmitter release. By binding to the alpha2-delta subunit, Miragabalin reduces the release of excitatory neurotransmitters such as glutamate and substance P, leading to a reduction in neuronal hyperexcitability.
Miragabalin's mechanism of action results in a reduction of chronic pain, particularly neuropathic pain and pain associated with fibromyalgia. It is believed to work by reducing the activity of nerve cells that transmit pain signals, which can result in a decrease in pain perception.
Miragabalin (brand name Neuramend) is indicated for the treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPN) and fibromyalgia.
Diabetic peripheral neuropathy is a type of nerve damage that can occur in people with diabetes and is characterized by pain, numbness, tingling, and weakness in the hands and feet. Fibromyalgia is a chronic pain disorder that is characterized by widespread musculoskeletal pain, fatigue, and tenderness in localized areas.
Miragabalin is used as an adjunctive treatment, which means it is used in combination with other pain medications to provide additional pain relief. It is taken orally and is available in tablet form.
Dr. Reddy's总部位于印度海得拉巴，是全球领先的活性药物成分（API）供应商之一。 Dr. Reddy's的API业务是美国、欧洲、巴西、拉丁美洲、日本、中国、韩国和新兴市场的制药公司的首选合作伙伴。
Dr. Reddy's博士的API业务在过去30多年来在开发和制造复杂API（如类固醇，多肽，复杂长链分子和高效API（HPAPI /肿瘤药物））方面所建立的深厚技术优势中茁壮成长。 我们在知识产权和法规事务方面的实力可以帮助我们始终如一地达到并超越监管标准，从而为这一专业知识提供补充。 Dr. Reddy's博士 Mirogabalin Besylate API是研发，知识产权和监管方面广泛专业知识的结果。
帮助我们的客户率先进入市场的关键组成部分是响应式供应链。 我们通过确保所有设施都高效运行并达到最新的质量，安全和生产率标准来实现这一目标。 业务和工厂之间的强大互联可以快速响应动态的市场变化，从而避免短缺并满足需求的突然激增。