关于 Seladelpar API
治疗类别 Hepatology（肝病学）
CAS 编号
851528‑79‑5
API 技术
Small‑molecule synthetic API
剂型
口服固体/胶囊
Dr Reddy's 开发状态
开发中
Mechanism of action
Seladelpar activates PPAR‑δ, a nuclear receptor expressed in the liver and other tissues.
PPAR‑δ activation:
Reduces bile acid synthesis via FGF21‑mediated downregulation of CYP7A1, the rate‑limiting enzyme in bile acid production
Decreases cholesterol synthesis and absorption
Lowers hepatic and circulating bile acid levels
These effects result in:
Reduced cholestatic liver injury
Improvement in biochemical markers (e.g., alkaline phosphatase)
Reduction in pruritus, partly associated with decreased interleukin‑31 levels
Indication
Approved indication (FDA / EMA):
Treatment of primary biliary cholangitis (PBC) in adults:
In combination with ursodeoxycholic acid (UDCA) in patients with inadequate response to UDCA, or
As monotherapy in patients unable to tolerate UDCA
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Related APIs
Seladelpar（司拉德帕）
Hepatology（肝病学）
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