关于 Upadacitinib API
治疗类别 Immunology（免疫学）
CAS 编号
1310726‑60‑3
API 技术
Small‑molecule synthetic API
剂型
片剂
Dr Reddy's 开发状态
开发中
Mechanism of action
Upadacitinib selectively inhibits JAK1, a key intracellular tyrosine kinase involved in the JAK‑STAT signaling pathway.
By blocking JAK1, upadacitinib:
Prevents phosphorylation and activation of STAT transcription factors
Inhibits signaling from multiple pro‑inflammatory cytokines (e.g., IL‑6, IL‑2, IL‑12, IL‑23, interferons)
Indication
Approved indications (FDA / EMA):
Rheumatoid arthritis (moderate to severe)
Psoriatic arthritis
Ankylosing spondylitis
Non‑radiographic axial spondyloarthritis
Atopic dermatitis (moderate to severe)
Ulcerative colitis
Crohn’s disease
Giant cell arteritis
Polyarticular juvenile idiopathic arthritis
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Related APIs
Upadacitinib（乌帕替尼）
Immunology（免疫学）
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