About Sitagliptin Phosphate (Anhydrous) API
Categoría Terapéutica Anti-diabético

Número CAS
654671-77-9
Tecnología del API
Sintética
Forma de Dosificación
Sólidos Orales
Estado de Desarrollo en Dr. Reddy’s
Disponible
Presentación Regulatoria Disponible
USDMF, DMF de Brasil, DMF de Canadá, DMF de Corea
Mechanism of Action
Sitagliptin works to competitively inhibit the enzyme dipeptidyl peptidase 4 (DPP-4). This enzyme breaks down the incretinsGLP-1 and GIP, gastrointestinal hormones released in response to a meal. By preventing GLP-1 and GIP inactivation, they are able to increase the secretion of insulin and suppress the release of glucagon by the alpha cells of the pancreas. This drives blood glucose levels towards normal. As the blood glucose level approaches normal, the amounts of insulin released and glucagon suppressed diminishes, thus tending to prevent an "overshoot" and subsequent low blood sugar (hypoglycemia) which is seen with some other oral hypoglycemic agents.
Indication
JANUVIA is a dipeptidyl peptidase-4 (DPP-4) inhibitor indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
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