Active Pharmaceutical Ingredients - Dr Reddy's
Active Pharmaceutical Ingredients - Dr Reddy's

About Apremilast (Form B) API

Product
  • Therapeutic Category Anti-Inflammatory

  • CAS Number

    608141-41-9

  • API Technology

    Synthetic

  • Dose Form

    Tablets

  • Dr Reddy's Development Status

    Available

  • Available Regulatory Filing

    Korea DMF, China DMF, USDMF

Mechanism of Action

Apremilast is an oral small-molecule inhibitor of phosphodiesterase 4 (PDE4) specific for cyclic adenosine monophosphate (cAMP). PDE4 inhibition results in increased intracellular cAMP levels. The specific mechanism(s) by which apremilast exerts its therapeutic action in psoriatic arthritis patients and psoriasis patients is not well defined.

Indication

OTEZLA, an inhibitor of phosphodiesterase 4 (PDE4), is indicated for the treatment of:

  • Adult patients with active psoriatic arthritis
  • Patients with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy

 

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Related APIs

Apremilast (Form B)

Anti-Inflammatory

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