About Desloratadine API
Therapeutic CategoryRespiratory
CAS Number
100643-71-8
API Technology
Synthetic
Dose Form
Syrup, Reditab
Dr Reddy's Development Status
Available
Available Regulatory Filing
USDMF, CEP Submitted, EUDMF
Mechanism of Action
Desloratadine is a long-acting tricyclic histamine antagonist with selective H1-receptor histamine antagonist activity. Receptor binding data indicates that at a concentration of 2-3 ng/mL (7 nanomolar), desloratadine shows significant interaction with the human histamine H1-receptor. Desloratadine inhibited histamine release from human mast cells in vitro. Results of a radiolabeled tissue distribution study in rats and a radioligand H1-receptor binding study in guinea pigs showed that desloratadine did not readily cross the blood brain barrier. The clinical significance of this finding is unknown.
Indication
CLARINEX is an H1-receptor antagonist indicated for:
- Seasonal Allergic Rhinitis: relief of nasal and non-nasal symptoms in patients 2 years of age and older.
- Perennial Allergic Rhinitis: relief of nasal and non-nasal symptoms in patients 6 months of age and older.
- Chronic Idiopathic Urticaria: symptomatic relief of pruritus, reduction in the number of hives, and size of hives in patients 6 months of age and older.
Related APIs
Cetirizine Dihydrochloride
Respiratory
Desloratadine
Respiratory
Levocetirizine Dihydrochloride
Respiratory
Montelukast Sodium
Respiratory
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