About Memantine Hydrochloride API
Therapeutic CategoryCentral Nervous System (CNS)
CAS Number
41100-52-1
API Technology
Synthetic
Dose Form
Oral Solid/Capsules, Solution/Tablet
Dr Reddy's Development Status
Available
Available Regulatory Filing
USDMF, Canada DMF, Russia DMF, China DMF
Mechanism of Action
Persistent activation of central nervous system N-methyl-D-aspartate (NMDA) receptors by the excitatory amino acid glutamate has been hypothesized to contribute to the symptomatology of Alzheimer’s disease. Memantine is postulated to exert its therapeutic effect through its action as a low to moderate affinity uncompetitive (open-channel) NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels. There is no evidence that memantine prevents or slows neurodegeneration in patients with Alzheimer’s disease.
Indication
NAMENDA is an N-methyl-D-aspartate (NMDA) receptor antagonist indicated for the treatment of moderate to severe dementia of the Alzheimer’s type.
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