About Quetiapine Fumarate API
Therapeutic Category Central Nervous System (CNS)
CAS Number
111974-72-2
API Technology
Synthetic
Dose Form
Oral Solid/Tablets
Dr Reddy's Development Status
Available
Available Regulatory Filing
USDMF, CEP Submitted, Brazil DMF, EUDMF, Canada DMF, Korea DMF, China DMF, Japan DMF
Mechanism of Action
"The mechanism of action of SEROQUEL is unknown. However, it has been proposed that the efficacy of SEROQUEL in schizophrenia and its mood stabilizing properties in bipolar depression and mania are mediated through a combination of dopamine type 2 (D2) and serotonin type 2 (5HT2) antagonism. Antagonism at receptors other than dopamine and 5HT2 with similar receptor affinities may explain some of the other effects of SEROQUEL. SEROQUEL’s antagonism of histamine H1 receptors may explain the somnolence observed with this drug. SEROQUEL’s antagonism of adrenergic α1 receptors may explain the orthostatic hypotension observed with this drug."
Indication
SEROQUEL is an atypical antipsychotic indicated for the treatment of:
- Schizophrenia
- Bipolar I disorder manic episodes
- Bipolar disorder, depressive episodes
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FAQs
Treats schizophrenia, bipolar disorder, and major depressive disorder
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Reduces psychotic, manic, and depressive episodes
Helps restore balance of serotonin and dopamine
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Avoid inhalation and skin contact
Use protective equipment
Store in a cool, dry place, away from light