CAS Number: 1381321-73-2
Therapeutic Category
Nonalcoholic steatohepatitis - NASH
API Technology
Small molecule
Dose Form
Oral Solid/Tablets
Dr Reddy's Development Status
Under-Development
Resmetirom works by specifically targeting the thyroid hormone receptor beta (THR-β) in the liver. Here's a breakdown of the key aspects:
Selective THR-β Activation: Unlike natural thyroid hormones or some drugs, Resmetirom primarily activates THR-β and has minimal effect on THR-α, another thyroid hormone receptor found throughout the body. This targeted action helps minimize potential side effects outside the liver.
Promoting Fatty Acid Metabolism: In a healthy liver, fatty acids are broken down for energy or eliminated. NASH is characterized by an accumulation of fat. Resmetirom activation of THR-β stimulates enzymes involved in fatty acid degradation and oxidation, leading to a reduction in liver fat content.
Potential Anti-inflammatory Effects: While the exact mechanism is still under investigation, THR-β activation by Resmetirom might also play a role in reducing inflammation in the liver, a hallmark of NASH. This could further contribute to improved liver function.
Resmetirom is approved for the treatment of noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis in adults. NASH is a liver condition characterized by fat accumulation, inflammation, and fibrosis (scarring). Resmetirom helps improve liver function by reducing fat and potentially inflammation.
Dr. Reddy's总部位于印度海得拉巴,是全球领先的活性药物成分(API)供应商之一。 Dr. Reddy's的API业务是美国、欧洲、巴西、拉丁美洲、日本、中国、韩国和新兴市场的制药公司的首选合作伙伴。
Dr. Reddy's博士的API业务在过去30多年来在开发和制造复杂API(如类固醇,多肽,复杂长链分子和高效API(HPAPI /肿瘤药物))方面所建立的深厚技术优势中茁壮成长。 我们在知识产权和法规事务方面的实力可以帮助我们始终如一地达到并超越监管标准,从而为这一专业知识提供补充。 Dr. Reddy's博士 瑞司美替罗 API是研发,知识产权和监管方面广泛专业知识的结果。
帮助我们的客户率先进入市场的关键组成部分是响应式供应链。 我们通过确保所有设施都高效运行并达到最新的质量,安全和生产率标准来实现这一目标。 业务和工厂之间的强大互联可以快速响应动态的市场变化,从而避免短缺并满足需求的突然激增。
本目錄中的任何信息(包括對任何產品或服務的任何引用)均不構成銷售要約,或被解釋為代表銷售要約。受有效專利保護的產品不提供或供應用於商業用途。但是,只要存在此類監管豁免,就可以出於監管提交的目的提供此類產品的研究數量。買方應對各自市場的專利方案進行獨立評估,並承擔所有與專利相關的責任。在印度受有效專利保護的產品不可用於商業用途,但可用於第 107A 節。
Sign-up for our email service to get Market and Product insights and updates right to your digital doorstep
The categories of personal information collected in this form include name, company, and contact information etc. The personal information collected will be used for exploratory discussions on contract manufacturing, marketing and to perform research and analytics and others. For more information about the categories of personal information collected by Dr.Reddy's and the purposes for which Dr.Reddy's uses personal information, visit https://api.drreddys.com/privacy-policy.
本目錄中的任何信息(包括對任何產品或服務的任何引用)均不構成銷售要約,或被解釋為代表銷售要約。受有效專利保護的產品不提供或供應用於商業用途。但是,只要存在此類監管豁免,就可以出於監管提交的目的提供此類產品的研究數量。買方應對各自市場的專利方案進行獨立評估,並承擔所有與專利相關的責任。在印度受有效專利保護的產品不可用於商業用途,但可用於第 107A 節。