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伊曲莫德

伊曲莫德 API

伊曲莫德-API

CAS Number: 1200452-31-1

治疗类别
Ulcerative Colitis
API技术
Small molecule
剂型
Oral Solid/Capsules
瑞迪博士研发状态
正在开发中
创新品牌(美国)
Velsipity (Pfizer)
No Document Available
Off
Region/Country
China

作用机制

Etrasimod works by targeting a molecule called sphingosine 1-phosphate (S1P). S1P has various roles in the body, including regulating the movement of immune cells, particularly lymphocytes. There are five types of S1P receptors (S1P1-5), and etrasimod binds with high affinity to three of them: S1P1, S1P4, and S1P5.

Here's a breakdown of how etrasimod affects lymphocytes:

Blocks lymphocyte egress: Normally, S1P signals lymphocytes to leave the lymph nodes and enter the bloodstream. By binding to S1P receptors, etrasimod partially blocks this signal. This reduces the number of lymphocytes circulating in the blood.

Reduces lymphocyte migration to intestines: In ulcerative colitis, there's an abnormal activation of immune cells in the intestines. While the exact mechanism isn't fully understood, the reduced number of circulating lymphocytes due to etrasimod's action is believed to lead to fewer lymphocytes migrating into the inflamed intestinal tissue. This helps to lessen inflammation and associated symptoms.

适应症

Etrasimod is specifically indicated for the treatment of moderately to severely active ulcerative colitis in adults. It's not a cure, but it can help manage symptoms like:

Diarrhea Rectal bleeding Abdominal pain Urgent need to have a bowel movement (tenesmus) Etrasimod is typically used when other medications haven't been effective in controlling the disease.

Dr. Reddy's的专长

Dr. Reddy's总部位于印度海得拉巴,是全球领先的活性药物成分(API)供应商之一。 Dr. Reddy's的API业务是美国、欧洲、巴西、拉丁美洲、日本、中国、韩国和新兴市场的制药公司的首选合作伙伴。

Dr. Reddy's博士的API业务在过去30多年来在开发和制造复杂API(如类固醇,多肽,复杂长链分子和高效API(HPAPI /肿瘤药物))方面所建立的深厚技术优势中茁壮成长。 我们在知识产权和法规事务方面的实力可以帮助我们始终如一地达到并超越监管标准,从而为这一专业知识提供补充。 Dr. Reddy's博士 伊曲莫德 API是研发,知识产权和监管方面广泛专业知识的结果。

帮助我们的客户率先进入市场的关键组成部分是响应式供应链。 我们通过确保所有设施都高效运行并达到最新的质量,安全和生产率标准来实现这一目标。 业务和工厂之间的强大互联可以快速响应动态的市场变化,从而避免短缺并满足需求的突然激增。

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免责声明

本目錄中的任何信息(包括對任何產品或服務的任何引用)均不構成銷售要約,或被解釋為代表銷售要約。受有效專利保護的產品不提供或供應用於商業用途。但是,只要存在此類監管豁免,就可以出於監管提交的目的提供此類產品的研究數量。買方應對各自市場的專利方案進行獨立評估,並承擔所有與專利相關的責任。在印度受有效專利保護的產品不可用於商業用途,但可用於第 107A 節。