关于 Hydroxychloroquine（羟氯喹） API
治疗类别 Anti‑Infective（抗感染）
CAS 编号
747-36-4
API 技术
合成
剂型
片剂
Dr Reddy's 开发状态
可用的
可用的法规申报文件
USDMF
Mechanism of Action
Malaria - The precise mechanism by which hydroxychloroquine exhibits activity against Plasmodium is not known. Hydroxychloroquine, like chloroquine, is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA.
Rheumatoid Arthritis and Systemic Lupus Erythematosus - The mechanisms underlying the anti-inflammatory and immunomodulatory effects of PLAQUENIL are unknown.
Indication
PLAQUENIL is indicated for the treatment of uncomplicated malaria due to P. falciparum, P. malariae, P. ovale, and P. vivax.
PLAQUENIL is indicated for the prophylaxis of malaria in geographic areas where chloroquine resistance is not reported.
PLAQUENIL is indicated for the treatment of chronic discoid lupus erythematosus and systemic lupus erythematosus in adults.
PLAQUENIL is indicated for the treatment of acute and chronic rheumatoid arthritis in adults.
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