Mechanism of Action

Malaria -  The precise mechanism by which hydroxychloroquine exhibits activity against Plasmodium is not known. Hydroxychloroquine, like chloroquine, is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA.

Rheumatoid Arthritis and Systemic Lupus Erythematosus - The mechanisms underlying the anti-inflammatory and immunomodulatory effects of PLAQUENIL are unknown.

Indication

PLAQUENIL is indicated for the treatment of uncomplicated malaria due to P. falciparum, P. malariae, P. ovale, and P. vivax.

PLAQUENIL is indicated for the prophylaxis of malaria in geographic areas where chloroquine resistance is not reported.

PLAQUENIL is indicated for the treatment of chronic discoid lupus erythematosus and systemic lupus erythematosus in adults.

PLAQUENIL is indicated for the treatment of acute and chronic rheumatoid arthritis in adults.