Product Alert – Mavacamten
CAS No. 1642288-47-8
Mavacamten is an allosteric and reversible inhibitor selective for cardiac myosin. Mavacamten modulates the number of myosin heads that can enter “on actin” (power-generating) states, thus reducing the probability of force-producing (systolic) and residual (diastolic) cross-bridge formation. Excess myosin actin cross-bridge formation and dysregulation of the super-relaxed state are mechanistic hallmarks of HCM. Mavacamten shifts the overall myosin population towards an energy-sparing, recruitable, super-relaxed state. In HCM patients, myosin inhibition with Mavacamten reduces dynamic LVOT obstruction and improves cardiac filling pressures.
Dr. Reddy's API Offering*:
- Potential NCE-1 filing opportunity.
- Crystalline Form A (Validated).
- USDMF filed and DMF's planned for all other major markets
- Planning adequate capacity with a short lead time of 90 days.
- Regulatory compliance and quality ensure our API is genotoxic and nitrosamine-free, adhering to ICH M7 guidelines.
- Reliable suppliers for KSMs to ensure timely deliveries and strict adherence to specifications.
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