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Cabozantinib HCl

Cabozantinib HCl API

Cabozantinib HCl-API

CAS Number: 1817759-42-4

Therapeutic Category
Anti-Cancer/ Oncology
API Technology
Dose Form
Oral Solid/Capsules
Dr Reddy's Development Status
Available Regulatory Filing
Innovator Brand (USA)

Mechanism of Action

Cabozantinib is a tyrosine kinase inhibitor that acts by blocking the activity of multiple tyrosine kinases, including MET and VEGFR2. Tyrosine kinases are enzymes that play a key role in signaling pathways that regulate cellular processes such as proliferation, migration, and angiogenesis.

In cancer, these signaling pathways are often dysregulated, leading to uncontrolled cell growth and survival. By inhibiting the activity of these kinases, cabozantinib can block these signaling pathways and potentially slow or stop the growth of cancer cells.

Specifically, cabozantinib has been shown to effectively inhibit the activity of MET, a tyrosine kinase that is overexpressed in many cancers and plays a key role in tumor growth, invasion, and angiogenesis. Inhibition of VEGFR2, another target of cabozantinib, can also block the growth of new blood vessels that tumors need to grow and spread.

Overall, the mechanism of action of cabozantinib involves blocking the activity of multiple tyrosine kinases involved in cancer cell growth and survival, ultimately leading to the inhibition of tumor growth.


Cabozantinib is an FDA-approved treatment for several types of cancer. It is indicated for the following indications:

Metastatic Renal Cell Carcinoma (mRCC): Cabozantinib is indicated for the treatment of patients with advanced or metastatic renal cell carcinoma (RCC) who have received prior anti-angiogenic therapy.

Medullary Thyroid Cancer (MTC): Cabozantinib is indicated for the treatment of patients with locally advanced or metastatic medullary thyroid cancer (MTC) who require systemic therapy and have received prior treatment with radioactive iodine.

Hormone-Relapsed Prostate Cancer: Cabozantinib is indicated for the treatment of patients with hormone-relapsed prostate cancer that has progressed during or after androgen deprivation therapy.

Advanced Liver Cancer: Cabozantinib is indicated for the treatment of patients with hepatocellular carcinoma who have been previously treated with sorafenib.

Dr. Reddy's Expertise

Headquartered in Hyderabad, India, Dr. Reddy's Laboratories is one of the leading Active Pharmaceutical Ingredients (API) manufacturers and suppliers globally for Cabozantinib HCl API. Dr. Reddy's API business is a preferred partner to pharma companies across the US, Europe, Brazil, Latin America, Japan, China, Korea, Middle East and other emerging markets.

Dr. Reddy's API business thrives on the deep technical strengths established over the last 30+ years in the development and manufacture of complex APIs such as steroids, peptides, complex long chain molecules and highly potent APIs (HPAPIs / oncology drugs). This expertise is complemented by our prowess in intellectual property and regulatory affairs which helps us consistently meet and exceed regulatory standards. Dr. Reddy's Cabozantinib HCl API is the outcome of the extensive expertise in R&D, IP, and Regulatory.

A key component in helping our customers be first to market is a responsive supply chain. We achieve this by making sure that all our facilities are operating efficiently and to the latest standards of quality, safety, and productivity. A strong interconnect between business and factories allows for a quick reaction to dynamic market changes, so that we can avert shortages and meet sudden surges in demand.

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No information in this catalog - including any reference to any product or service - constitutes an offer for sale, or be construed as representing an offer for sale. Products protected under valid patents are not offered or supplied for commercial use. However, the research quantities of such products may be offered for the purpose of regulatory submissions, wherever such regulatory exemptions exist. The buyers should make their independent evaluation of the patent scenario for their respective markets and will be responsible for all patent related liabilities. Products protected under valid patents in India are not available for commercial use but would be available for Section 107A purposes.