CAS Number: 154361-50-9
Enzymes convert capecitabine to 5-fluorouracil (5-FU) in vivo. Both normal and tumor cells metabolize 5-FU to 5-fluoro-2’-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). These metabolites cause cell injury by two different mechanisms. First, FdUMP and the folate cofactor, N5-10-methylenetetrahydrofolate, bind to thymidylate synthase (TS) to form a covalently bound ternary complex. This binding inhibits the formation of thymidylate from 2’-deoxyuridylate. Thymidylate is the necessary precursor of thymidine triphosphate, which is essential for the synthesis of DNA, so that a deficiency of this compound can inhibit cell division. Second, nuclear transcriptional enzymes can mistakenly incorporate FUTP in place of uridine triphosphate (UTP) during the synthesis of RNA. This metabolic error can interfere with RNA processing and protein synthesis.
XELODA (capecitabine) is a nucleoside metabolic inhibitor with antineoplastic activity indicated for:
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It is used to treat Breast cancer, gastric cancer and colorectal cancer.
Available in oral tablet form - 150mg & 500 mg
Capecitabine belongs to the group of medicines called antineoplastics (cancer medicines).
Allergy to 5-fluorouracil or. Kidney disease, severe or. Shortage of an enzyme called dihydropyrimidine dehydrogenase (DPD) that your body needs.
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