Darolutamide API

Mechanism of Action

Darolutamide belongs to a class of drugs called androgen receptor antagonists. Here's how it disrupts prostate cancer cell growth:

Androgen and Androgen Receptors: Prostate cancer cells rely on male hormones called androgens, particularly testosterone, to grow and survive. These androgens bind to androgen receptors located inside the cancer cells.

Blocking Androgen Binding: Darolutamide acts by competitively binding to these androgen receptors. By occupying the receptor sites, it prevents testosterone and other androgens from attaching and triggering growth signals.

Downstream Effects: This blockade disrupts the normal function of androgen receptors, ultimately leading to a decrease in prostate cancer cell proliferation and potentially a reduction in tumor size.

Indication

Darolutamide is currently approved for two main indications in adult males:

Non-Metastatic Castration-Resistant Prostate Cancer (nmCRPC): This refers to prostate cancer that has not yet spread to other parts of the body (non-metastatic) but is no longer responding to treatments that lower testosterone levels (castration-resistant). Darolutamide is typically used in combination with surgical or medical castration.

Metastatic Hormone-Sensitive Prostate Cancer (mHSPC): This is a more advanced stage of prostate cancer where the cancer has already spread (metastatic) but still responds to lowering testosterone levels (hormone-sensitive). Here, Darolutamide is used in combination with docetaxel (chemotherapy medication).