关于 Aficamten API
治疗类别 Cardiology
CAS 编号
2364554‑48‑1
API 技术
Small‑molecule synthetic API
剂型
片剂
Dr Reddy's 开发状态
开发中
Mechanism of action
Aficamten binds directly to the catalytic (motor) domain of cardiac myosin (β‑myosin heavy chain).
It stabilizes myosin in a weak actin‑binding state, preventing transition into the force‑generating state.
This reduces the number of active myosin heads, resulting in:
Decreased myocardial hypercontractility
Reduced left ventricular outflow tract (LVOT) obstruction
Overall effect: improved diastolic function and symptom relief in obstructive hypertrophic cardiomyopathy (oHCM).
Indication
Treatment of adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM) to:
Improve functional capacity
Reduce symptoms such as dyspnea and exercise intolerance
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Related APIs
Acoramidis（阿可拉米地）
Cardiology
Aficamten（阿夫凯泰）
Cardiology
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