关于 Acoramidis API
治疗类别 Cardiology（心血管）
CAS 编号
1446711‑81‑4
API 技术
Small‑molecule synthetic API
剂型
片剂
Dr Reddy's 开发状态
开发中
Mechanism of action
Acoramidis selectively binds to transthyretin (TTR) at the thyroxine‑binding sites.
Stabilizes the TTR tetramer, preventing dissociation into misfolded monomers.
This inhibition prevents amyloid fibril formation and cardiac amyloid deposition.
Demonstrates >90% TTR stabilization across wild‑type and variant TTR genotypes.
Indication
Indicated to reduce cardiovascular death and cardiovascular‑related hospitalization in adult patients with:
Wild‑type or variant transthyretin‑mediated amyloid cardiomyopathy (ATTR‑CM)
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