Active Pharmaceutical Ingredients - Dr Reddy's
Active Pharmaceutical Ingredients - Dr Reddy's

关于 Suzetrigine API

Product
  • 治疗类别 疼痛管理

  • CAS 编号

    2649467‑58‑1

  • API 技术

    Small‑molecule synthetic API

  • 剂型

    片剂

  • Dr Reddy's 开发状态

    开发中

Mechanism of action 

Suzetrigine selectively inhibits the Naᵥ1.8 voltage‑gated sodium channel, which is predominantly expressed in peripheral pain‑sensing (nociceptive) neurons of the dorsal root ganglia.
It binds to the second voltage‑sensing domain (VSD2) of Naᵥ1.8 and stabilizes the channel in a closed (inactive) state.


Indication 

Approved indication (FDA):

Treatment of moderate to severe acute pain in adults

 

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Disclaimer: Products under patent(s) are offered only for R&D purposes U/S 107A of the Patent Act (Bolar Exemption) and not for commercial sale.