About Tafamidis Free Acid API
Therapeutic CategoryCardiovascular
CAS Number
594839-88-0
API Technology
Synthetic
Dose Form
Oral Solid/Capsules
Dr Reddy's Development Status
Under Development
Mechanism of Action
Tafamidis free acid is a transthyretin stabilizer. It works by binding to the thyroxine-binding sites of transthyretin tetramers, stabilizing them and reducing the dissociation into monomers, which prevents amyloid formation
Indication
Tafamidis free acid is indicated for the treatment of cardiomyopathy caused by wild-type or hereditary transthyretin-mediated amyloidosis (ATTR-CM) in adults, to reduce cardiovascular mortality and cardiovascular-related hospitalization
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