About Treprostinil API
Therapeutic CategoryCardiovascular
CAS Number
81846-19-7
API Technology
Synthetic
Dose Form
Oral Solid/Tablets, Injectable, Solution
Dr Reddy's Development Status
Available
Available Regulatory Filing
USDMF, EUDMF, Canada DMF, Israel DMF
Mechanism of Action
The major pharmacologic actions of treprostinil are direct vasodilation of pulmonary and systemic arterial vascular beds, and inhibition of platelet aggregation.
Indication
Remodulin is a prostacyclin vasodilator indicated for:
- Treatment of pulmonary arterial hypertension (PAH; WHO Group 1) to diminish symptoms associated with exercise. Studies establishing effectiveness included patients with NYHA Functional Class II-IV symptoms and etiologies of idiopathic or heritable PAH (58%), PAH associated with congenital systemic-to-pulmonary shunts (23%), or PAH associated with connective tissue diseases (19%).
- Patients who require transition from epoprostenol, to reduce the rate of clinical deterioration. The risks and benefits of each drug should be carefully considered prior to transition.
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