关于 Empagliflozin API
治疗类别 Anti‑Diabetic（抗糖尿病）
CAS 编号
864070-44-0
API 技术
合成
剂型
片剂
Dr Reddy's 开发状态
可用的
可用的法规申报文件
USDMF, 韩国 DMF, 加拿大 DMF, 新加坡 DMF, Australia DMF, Saudi Arabia, 马来西亚 DMF
Mechanism of Action
Sodium-glucose co-transporter 2 (SGLT2) is the predominant transporter responsible for reabsorption of glucose from the glomerular filtrate back into the circulation. Empagliflozin is an inhibitor of SGLT2. By inhibiting SGLT2, empagliflozin reduces renal reabsorption of filtered glucose and lowers the renal threshold for glucose, and thereby increases urinary glucose excretion.
Indication
JARDIANCE is a sodium-glucose co-transporter 2 (SGLT2) inhibitor indicated:
- As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus,
- To reduce the risk of cardiovascular death in adult patients with type 2 diabetes mellitus and established cardiovascular disease
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