Sorry, you need to enable JavaScript to visit this website.
跳转到主要内容


盐酸帕洛诺司琼

盐酸帕洛诺司琼
CAS Number: 135729-62-3

盐酸帕洛诺司琼

治疗类别
止吐
API技术
高效API
剂型
口服固体制剂
注射剂
瑞迪博士研发状态
可得到
注册备案情况
USA
Europe
Australia
Korea
Saudi Arabia
创新品牌(美国)
ALOXI

Mechanism of Action

Palonosetron is a 5-HT3 receptor antagonist with a strong binding affinity for this receptor and little or no affinity for other receptors.

Cancer chemotherapy may be associated with a high incidence of nausea and vomiting, particularly when certain agents, such as cisplatin, are used. 5-HT3 receptors are located on the nerve terminals of the vagus in the periphery and centrally in the chemoreceptor trigger zone of the area postrema. It is thought that chemotherapeutic agents produce nausea and vomiting by releasing serotonin from the enterochromaffin cells of the small intestine and that the released serotonin then activates 5-HT3 receptors located on vagal afferents to initiate the vomiting reflex.

Postoperative nausea and vomiting is influenced by multiple patient, surgical and anesthesia related factors and is triggered by release of 5-HT in a cascade of neuronal events involving both the central nervous system and the gastrointestinal tract. The 5-HT3 receptor has been demonstrated to selectively participate in the emetic response.

Indication

ALOXI is a serotonin-3 (5-HT3) receptor antagonist indicated in adults for:

  • Moderately emetogenic cancer chemotherapy --prevention of acute and delayed nausea and vomiting associated with initial and repeat courses
  • Highly emetogenic cancer chemotherapy --prevention of acute nausea and vomiting associated with initial and repeat courses
  • Prevention of postoperative nausea and vomiting (PONV) for up to 24 hours following surgery. Efficacy beyond 24 hours has not been demonstrated 

ALOXI is indicated in pediatric patients aged 1 month to less than 17 years for:

  • Prevention of acute nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including highly emetogenic cancer chemotherapy

Dr. Reddy的专长

Dr. Reddy总部位于印度海得拉巴,是全球领先的活性药物成分(API)供应商之一。 Dr. Reddy的API业务是美国、欧洲、巴西、拉丁美洲、日本、中国、韩国和新兴市场的制药公司的首选合作伙伴。

Reddy博士的API业务在过去30多年来在开发和制造复杂API(如类固醇,多肽,复杂长链分子和高效API(HPAPI /肿瘤药物))方面所建立的深厚技术优势中茁壮成长。 我们在知识产权和法规事务方面的实力可以帮助我们始终如一地达到并超越监管标准,从而为这一专业知识提供补充。 Reddy博士 盐酸帕洛诺司琼 API是研发,知识产权和监管方面广泛专业知识的结果。

帮助我们的客户率先进入市场的关键组成部分是响应式供应链。 我们通过确保所有设施都高效运行并达到最新的质量,安全和生产率标准来实现这一目标。 业务和工厂之间的强大互联可以快速响应动态的市场变化,从而避免短缺并满足需求的突然激增。

如果您有任何特定于国家的要求,我们将为您提供帮助。

联系我们

联系我们

请填写以下表格,我们会尽快与您联系

给我们发电子邮件: api@drreddys.com |   +91 40 49002253

免责声明

受有效专利保护的产品不得在销售此类产品构成专利侵权的国家/地区销售。可获得性可能仅限于某些市场或国家/地区。有关可获得性和产品适用性的更多信息,请 我们联系 .

所有产品信息,包括有关活性药物成分(API)、适应症和可能的作用机制的信息均基于公开的产品标签。

  给我们发电子邮件: api@drreddys.com |   +91 40 49002253