CAS Number: 943332-08-9
Selumetinib sulfate is a kinase inhibitor, a type of medication that works by blocking the activity of certain enzymes called kinases. Selumetinib sulfate specifically targets two kinases, MEK1 and MEK2, which play a critical role in the signaling pathways that regulate cell growth and division.
In cancer cells, mutations in genes that regulate these signaling pathways can lead to their overactivity, driving the uncontrolled growth and division of the cells. Selumetinib sulfate works by blocking the activity of MEK1/2, thereby interrupting these abnormal signaling pathways and slowing down the progression of the cancer.
Selumetinib sulfate is used to treat certain types of cancer, including non-small cell lung cancer, hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC), and neurofibromatosis type 1-associated plexiform neurofibromas. The drug is administered orally and works by targeting the cancer cells directly, reducing their ability to grow and divide.
Selumetinib sulfate is a medication used for the treatment of certain types of cancer. It is indicated for the treatment of:
Non-small cell lung cancer (NSCLC): Selumetinib sulfate is indicated for the treatment of adult patients with NSCLC whose tumors have a specific genetic mutation (BRAF V600E).
Hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC): Selumetinib sulfate is indicated for the treatment of adult patients with HLRCC-associated renal cell carcinoma.
Neurofibromatosis type 1-associated plexiform neurofibromas: Selumetinib sulfate is indicated for the treatment of adult and pediatric patients 2 years of age and older with symptomatic, inoperable plexiform neurofibromas associated with neurofibromatosis type 1.
Headquartered in Hyderabad, India, Dr. Reddy's Laboratories is one of the leading Active Pharmaceutical Ingredients (API) manufacturers and suppliers globally for Selumetinib Sulfate API. Dr. Reddy's API business is a preferred partner to pharma companies across the US, Europe, Brazil, Latin America, Japan, China, Korea, Middle East and other emerging markets.
Dr. Reddy's API business thrives on the deep technical strengths established over the last 30+ years in the development and manufacture of complex APIs such as steroids, peptides, complex long chain molecules and highly potent APIs (HPAPIs / oncology drugs). This expertise is complemented by our prowess in intellectual property and regulatory affairs which helps us consistently meet and exceed regulatory standards. Dr. Reddy's Selumetinib Sulfate API is the outcome of the extensive expertise in R&D, IP, and Regulatory.
A key component in helping our customers be first to market is a responsive supply chain. We achieve this by making sure that all our facilities are operating efficiently and to the latest standards of quality, safety, and productivity. A strong interconnect between business and factories allows for a quick reaction to dynamic market changes, so that we can avert shortages and meet sudden surges in demand.
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